Research

A nonrandomized multicenter observational study of all reirradiation in patients with head and neck cancer with special focus on patients receiving proton therapy.

Reirradiation of head and neck cancer where patients are planned with conventional radiotherapy and proton therapy and assigned to the treatment that is considered the best.

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Photon therapy versus proton therapy in early tonsil cancer.

Patients with early tonsil cancer are randomized to receive radiation therapy with either photons (usual treatment), which is given at their home hospital, or with protons, which is given in Uppsala. The aim is to see if there is a difference in the side effect profile.

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A unique collaboration between Swedish and Norwegian researchers. Together they will find out whether radiation therapy with protons or photons is most suitable for patients with slow-growing gliomas, IDH-mutated diffuse gliomas.

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Article on the study

Clinical investigation of PBS proton treatment in Hodgkin lymphoma patients

Study of proton treatment in Hodgkin’s lymphoma. Patients receiving photons are included as a control group.

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Article from October 2018
Article from Nov 2019
Article from Dec 2022

Comparison between protons and photons in preoperative radiotherapy of high-risk rectal cancer.

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Article: New study on radiotherapy for rectal cancer
Article: The first patients in the PRORECT study…

Proton therapy of thymic malignancies: Prospective, non-randomized phase II study.

The purpose of the study is to compare that proton therapy is as effective as photon therapy but that the risk of late complications from nearby organs such as the lung and heart is less as the radiation dose is lower to these organs.

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Article: Prothym seeks knowledge about a rare diagnosis

Comparison between protons and photons in anal cancer.

Article on the study

A network project with EU funding from 2018 to 2022, it aimed to integrate research resources and equipment in proton therapy so that European researchers have access to a common state-of-the-art platform.

Assessing the risk of adverse effects from medical radiation exposure in the treatment of patients with lymphoma or brain tumors.

The EU-funded SINFONIA project aims to develop new methods and tools to assess the risk of adverse effects of radiation therapy. The project examines the risk to patients, healthcare professionals, the public and the environment from the treatment of patients with suspected or confirmed lymphoma or brain tumors. The project examines radiation doses from radiotherapy and imaging.

An important work that the Skandion Clinic contributes to the SINFONIA project is to map the neutron doses during treatment with proton radiation. This is done using Monte Carlo simulations and measurements. When shallow brain and lymphoma tumors are to be treated with proton radiation, it may be necessary to use a so-called range shifter and the neutron production in this element is also of interest in the Skandion Clinic’s mapping.

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A project with funding from Vinnova and the EU 2021-2024. It aims to develop equipment that can localize how the radiation dose is deposited during treatment. Protons can thus become a more effective and safer treatment option for even more patients.

A 2023-2026 project funded by the Swedish Cancer Society. It aims to use new imaging techniques (photon counting CT) to reduce physical uncertainty so that the radiation dose is delivered with greater precision to the patient.

A 2024-2027 project with EU funding. It aims to improve dose estimates for pregnant or potentially pregnant patients.

Group aim: To describe and compare the effect, impact and experience, from the patient’s perspective, of treatment with proton therapy compared to conventional radiotherapy.

Published work:

• Symptom clusters in patients with brain tumors undergoing proton beam therapy.
• The Art of Living with Symptoms: A Qualitative Study Among Patients with Primary Brain Tumors Receiving Proton Beam Therapy
• Evaluating quality of care in relation to health-related quality of life in patients diagnosed with a brain tumor.
• Coping with a changing social context – patients’ experiences of staying away from home while undergoing proton beam therapy.

Article: Ulrica Langegård’s doctoral thesis, part of the ProtonCare group’s work

The completed game can facilitate the implementation of radiation therapy for children. The game can be used nationally as a preparation material and thus all children receive similar information regardless of where they live, and can contribute to increased knowledge, autonomy, reduce fear and anxiety. In the longer term, the number of anaesthetics could be reduced during radiotherapy.

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Read the article about the study

Registry study collecting data on all children undergoing radiotherapy.

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